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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
20.91
Human Site:
T477
Identified Species:
35.38
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
T477
D
V
E
E
R
P
R
T
T
L
I
I
C
P
L
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
T477
D
V
E
E
R
P
R
T
T
L
I
I
C
P
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
T574
D
I
E
D
R
P
R
T
T
L
I
I
C
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
A471
D
T
G
E
R
T
R
A
T
L
I
I
C
P
L
Rat
Rattus norvegicus
NP_001099948
974
110023
T442
D
T
G
E
R
T
R
T
T
L
I
I
C
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
L432
I
R
W
L
R
V
I
L
D
E
G
H
T
I
R
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
T467
G
P
E
E
R
R
R
T
T
L
I
I
C
P
L
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
S457
Y
G
S
E
R
N
R
S
V
S
L
L
S
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
G525
G
R
K
D
T
R
R
G
G
T
L
V
V
C
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
A553
G
D
A
A
K
P
R
A
T
L
I
L
C
P
L
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
K347
P
W
E
D
S
P
V
K
K
I
D
W
C
R
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
M429
E
D
S
P
V
K
K
M
E
W
L
R
I
I
L
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
V338
Q
S
N
T
A
R
A
V
N
N
L
K
T
Q
K
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
T635
T
T
I
D
A
P
C
T
T
L
V
V
A
P
M
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
86.6
N.A.
73.3
80
N.A.
6.6
N.A.
80
20
N.A.
6.6
N.A.
N.A.
53.3
P-Site Similarity:
100
100
N.A.
100
N.A.
73.3
80
N.A.
6.6
N.A.
80
40
N.A.
33.3
N.A.
N.A.
66.6
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
20
N.A.
N.A.
6.6
0
33.3
P-Site Similarity:
40
N.A.
N.A.
26.6
6.6
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
15
0
8
15
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
58
8
0
% C
% Asp:
36
15
0
29
0
0
0
0
8
0
8
0
0
0
0
% D
% Glu:
8
0
36
43
0
0
0
0
8
8
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
22
8
15
0
0
0
0
8
8
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
8
8
0
0
0
8
0
0
8
50
43
8
15
0
% I
% Lys:
0
0
8
0
8
8
8
8
8
0
0
8
0
0
8
% K
% Leu:
0
0
0
8
0
0
0
8
0
58
29
15
0
0
58
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
0
8
0
0
8
8
0
0
0
0
0
% N
% Pro:
8
8
0
8
0
43
0
0
0
0
0
0
0
58
8
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
15
0
0
58
22
65
0
0
0
0
8
0
8
8
% R
% Ser:
0
8
15
0
8
0
0
8
0
8
0
0
8
0
0
% S
% Thr:
8
22
0
8
8
15
0
43
58
8
0
0
15
0
0
% T
% Val:
0
15
0
0
8
8
8
8
8
0
8
15
8
0
8
% V
% Trp:
0
8
8
0
0
0
0
0
0
8
0
8
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _